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Following endogenous Sororin depletion, the cohesin subunit SMC1 remained largely chromosome-associated in H2B-SororinCTR-GFP cells, but was efficiently removed in H2B-GFP cells (Fig

10.1021/acschemneuro.2c00565 310 WeilR

The dosing schedule began at 14 mg in week 1, followed by 28 mg (week 2), 42 mg (week 3), and 56 mg for five consecutive weekly administrations (week 4, 5, 6, 7, 8)