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The anti-inflammatory effect of curcumin is most likely associated with its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS) (164)

These include inhibitors such as pyrrolidine dithiobarbamate (PDTC) (Wetli et al., 2006) and benzylisothiourea (Zhang et al., 2012)

doi: 10.1038/s41572-024-00511-3 6 SafiriSNooriMNejadghaderiSAKaramzadNCarson-ChahhoudKSullmanMJet al

Pre-Treatment and Post-Treatment Proper preparation and aftercare improve treatment effectiveness and safety

A few years later, in 2004 and 2006, other researchers [9,76] supplemented the previously published study with new results that additionally pointed to the positive effect of the peptide in reducing the physiological and behavioral negative effects triggered by acute or chronic alcohol consumption