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doi: 10.3389/fimmu.2017.00070 33 ChawlaA

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Description IGF-1 LR3 is a synthetic elongated analogue of insulin-like growth factor 1 (IGF-1), engineered with an N-terminal arginine-based extension that reduces IGF-binding protein (IGFBP) affinity and extends plasma half-life relative to endogenous IGF-1

Mechanistically, GAS5 inhibits proliferation and promotes apoptosis through the regulation of E2F1, p21, and p53, and suppresses oncogenic pathways including EGFR, MAPK, and AKT

In longitudinal models, which included interactions with time, there were significant interactions between VDD and pack-years of smoking in association with the rate of FEV 1 decline ( P = 0.02) and a trend toward significance with FVC decline ( P = 0.08) and with smoking status in relation to FEV 1 ( P = 0.052) and to FEV 1 /FVC decline ( P = 0.02), where smokers with VDD had greater lung function decline compared with those without VDD