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Studies have confirmed that various immune cells, including T cells, macrophages, NK cells, and DCs, proceeded metabolism remodeling to fulfill their specific functions in discrete contexts

Considering that variants in FTO showed high correlation with body weight and also interact with dopamine signaling in the brain, a clinical trial was designed to develop a genotype-specific and individualized therapy approach for obesity targeting FTO (rs8050136) variant (NCT03525002)

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10.1152/physiol.00041.2015 160 SacksD