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Adherence to COFEPRIS Standards in Mexico In Mexico, the federal health authority in charge of regulating all medical treatments, drugs, and facilities is COFEPRIS (the Federal Commission for the Protection against Sanitary Risks)

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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)