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The total of four conversions of NAD + to NADH in the joint glutamate synthesis/oxidation process suggested [two in astrocytes during the production of -ketoglutarate and one during glutamate oxidation (Figure 3B), together with one in neurons (Figure 5)] may explain the close to 1:1 ratio between rates of glucose oxidation and of glutamine/glutamate (GABA) cycle flux

2023 Feb 10;15(4):892

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This finding is consistent with the findings of numerous studies that have reported anxiolytic effects of Mg

Collectively, these findings establish ROS as critical enablers of HCC metastasis, orchestrating EMT, proteolytic matrix degradation, and distant organ colonization through coordinated activation of ERK/AKT, JNK, and NF-B signaling [91], thereby providing a mechanistic basis for the link between oxidative stress and poor clinical outcomes in HCC