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Nat Rev Neurosci 10: 647658 [DOI] [PubMed] [Google Scholar] Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, Jan LY 2005

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On the basis of this new information, in 1966 Jerne speculated that 'Since a single antibody molecule contains only one type of heavy chain and one type of light chain in its subunits, this heterogeneity permits at least 14 types of antibody molecules that can have combining sites of the same "specificity."' He continued, 'It would seem that at any given time a plasma cell generally produces antibody molecules of only one specificity and composed of only one type of heavy chain and one type of light chain.' The problem at this point, he argued, 'There is still no reliable estimate of the number of different antibody combining sites that an animal can produce