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Footnotes Author Contributions Conceived and designed the experiments: MME, SS, NB, SA-A

PubMed PMID: 9879640

74 Additionally, the fact that gp91phox knockout mice, which lack functional NADPH oxidase (the main producer of superoxide in phagocytes), neither showed reduced peroxynitrite formation nor protection against APAP toxicity suggested that phagocytes, including Kupffer cells, cannot be the source of superoxide

Selected DEL7 analogs ( 2, 5 , and 10 ) were purchased from chemical vendor Curia

GH produced by the anterior pituitary regulates the biosynthesis and release of IGF-1 by the liver and peripheral tissues