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It is found in high concentrations in the liver, where it binds to heavy metals, such as mercury and lead, chemical pollutants and carcinogens, and then transforms them into a form that can be easily flushed out of the body via enzymatic pathways

Therefore, to experimentally compare the outcomes of ABHD11 inhibition to glutarate accumulation, we used HeLa cells as a well-studied cancer cell line, alongside primary human CD8 + T lymphocytes, where the effects of DEG have been well characterized 9

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