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There are other rare side effects associated with high doses or long term use, including kidney injury

Saenger S, Holtmann B, Nilges MR, Schroeder S, Hoeflich A, Kletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M et al (2012) Functional improvement in mouse models of familial amyotrophic lateral sclerosis by pegylated insulin-like growth factor i treatment depends on disease severity

Its still not entirely clear how IGF-1 may contribute to cancer

And when researchers combine them, the result is a metabolic environment where fat breaks down faster while appetite drops simultaneously

van Ommen B, Stierum R (2002) Nutrigenomics: exploiting systems biology in the nutrition and health arena