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3.6.2 Spatiotemporally controlled sustained-release platforms Microsphere/liposome systems: PLGA- or lipid-encapsulated uricase formulations achieve weeks-to-months sustained release, reducing injection frequency and improving adherence in chronic regimens (Ezike et al., 2023)
However, in many cases peripheral symptoms, such as muscle fatigue, either prevail or are an important part of the clinical presentation
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