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Discussion Our study discovered that NF1 unexpectedly acted as an oncogene in GBC by stabilizing YAP1, contradicting its previously observed protective effects

Findings from animal models further support these observations, demonstrating that serum lactate levels are consistently elevated in monocrotaline-induced PH [57]

doi: 10.3389/fphar.2021.771940 203 D'SouzaKParamelGVKienesbergerPC

However, overexpression of myo-inositol oxygenase (MIOX) can aggravate cisplatin-induced ferroptosis in the context of AKI by downregulating GPX4 activity, promoting lipid peroxidation and increasing the ferritinophagy rate [172]

CRISPR-Cas9 whole genome-wide gene-knockout screens for suppressors and enhancers of C9orf72 DPRs in human cells revealed TMX2 as an important protective modifier against toxicity (Kramer et al., 2018)