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This effect was achieved through the upregulation of hTERT (human telomerase reverse transcriptase) mRNA expression and a subsequent increase in telomerase enzyme activity

Mesa RA, Hanson CA, Rajkumar SV, Schroeder G, Tefferi A

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Brain iNOS (inducible Nitric Oxide synthase) has a circadian variation and increases with sleep propensity

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