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Samples were collected at the Hospital Universitario de La Princesa

To further explore the correlation between m 6 A fraction levels and mRNA stability, we divided mRNA carrying the 3 UTR-only and non- 3 UTR m 6 A sites into five groups based on m 6 A levels, and found that higher m 6 A fractions are associated with higher mRNA stability in those genes bearing the 3 UTR-only m 6 A sites (Fig

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More patients have been diagnosed since the inclusion of lcFAODs in NBS panels, often before development of symptoms and it is debated whether dietary restrictions should be alleviated in certain patient groups [147, 148]

Those with a compromised immune system Those feeling the effects of winter ills and chills Those who are feeling run down / tired / stressed Those participating in strenuous exercise / lead very active lifestyles People who are travelling Smokers and those who consume high levels of alcohol People with pre-existing conditions for which vitamin C is recommended as a complementary therapy Those living in urban areas (due to elevated levels of pollution) *Based on a clinical study comparing 10g Vitamin C Lipo-Sachets to 10g standard vitamin C