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In particular, marked karyopyknosis of pyramidal cells of the hippocampus was observed, followed by moderate karyopyknosis and degeneration of Purkinje cells of the cerebellar cortex
The mechanism appears to involve stimulation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activity, leading to accelerated triglyceride hydrolysis and increased free fatty acid release
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