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Intramuscular replacement therapy is indicated for patients with: Significant B12 deficiency (thresholds depend on local laboratory reference ranges) Neurological symptoms or signs Pernicious anaemia Malabsorption syndromes The standard UK regimen for patients without neurological involvement involves hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance injections every 2-3 months (often 3-monthly)
Figure 3 Potential future candidates for the treatment of cancer cachexia [11] In this study [11] , the researchers investigated the efficacy of BPC157 in a cancer cachexia model induced by C26 adenocarcinoma cells in Balb/c mice
Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency
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