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In Vitro Cell Dev Biol Anim 59(9):729737

As might be expected, the predominant composition of an individuals gut microbiota is determined by the geographic location as well as the dietary composition of an individual

Therefore, high NO concentration detected in the pathophysiology of neuropathic pain together with nicorandil NO donation may result in negative feedback inhibition of NOS enzymes

Thus, re-balancing of healthy gut microbiota through probiotics, prebiotics, and immune nutrients, could help reduce inflammation, promote anti-inflammatory mechanisms, and reset a functional gut-brain axis for optimal recovery of COVID-19 and PASC patients
