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The structure was based on phase and amplitude Fourier component information from cryo electron microscopy (cryoEM) images and electron diffraction, respectively

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Radiographics 31(7):1847-61

Riboflavin is critical to the proper functioning of mitochondrial pathways, and mitochondrial dysfunction linked to riboflavin deficiency is linked to many neurological conditions, including AD, PD, MS, Alper's syndrome, and Kearns Sayre Syndrome, reviewed in Ref

However, soluble -synuclein undergoes aggregation and misfolding under various pathological conditions, including compromised membrane-binding capacity, exposure to dopamine oxidation products or metal ions, or impaired autophagy/proteasome degradation system