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van de Donk T, Niesters M, Kowal MA, Olofsen E, Dahan A, van Velzen M (2019) An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia

Levodopa Levodopa has been shown in numerous placebo-controlled randomised trials to be effective in treating RLS (Limousin et al., 2018) levodopa was found to be useful in treating nocturnal symptoms of restless legs syndrome as well as improving both the subjective and objective quality of sleep-in patients with idiopathic and uraemic disease

In men, evidence is unclear and inconclusive, while in women (in particular suffering from PCOS) the supplementation with CoQ 10 demonstrated to improve the metabolic disorder, typically associated to the disease

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