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AIE compounds are a class of luminescent materials that were initially described by Luo et al

Hu, Q., Yin, L., Jagusch, C., Hille, U

The use of Bupleurum in the treatment of depression has a history of over a thousand years

Third, the one-week washout interval, although sufficient to reverse most clinical effects, may not completely eliminate slower-resolving mediators, potentially attenuating periodtoperiod contrasts

These observations strongly support the current hypothesis that reactive metabolite formation and protein binding especially in mitochondria are the key initiating events in the toxicity, which is then the trigger for a moderate mitochondrial oxidant stress with release of superoxide by complex III towards the cytosol without compromise of mitochondrial respiration [33]