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These findings, drawn from a large sample, replicate and expand upon prior data pointing to body temperature alterations as potentially relevant factors in depression etiology and may hold implications for development of novel approaches to the treatment of major depressive disorder

In cell models, glutathione participates in reversible protein glutathionylation, a process that can influence proteins involved in DNA repair pathways

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Discussion Previous studies have demonstrated that IGF-1 can regulate hematopoiesis and diverse functions of cells of the innate and acquired immune systems 17,18,19,20,21
