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pylori infection significantly affects the gastric microenvironment by several changes including DNA instability, disruption of NF-B signaling pathway, as well as differentiation of autoreactive B cells and subsequent malignant transformation by genomic alternations [132, 133]

And when they finally got to look at the numbers-- and that's why this has probably been delayed so much-- is that the two-shot regimen from Pfizer really wasn't all that revealing or encouraging

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The lead variant and the posterior probability for each multi-trait colocalization are shown