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Several in vitro and in vivo therapeutic studies have shown that SOD2 lipophilic mimic, Mn (III) meso-tetrakis (N-n-hexylpyridinium-2-yl) porphyrin, (H2O) MnTnHex-2-PyP5 + (MnHex) can cross the BBB and accumulate in mitochondria than cytosol (Leu D et al., 2017

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[DOI] [PMC free article] [PubMed] [Google Scholar] Vazquez F, Lim J-H, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, et al

Moreover, it has been found that the rat renal proximal cells metabolize these adducts to cysteinylglycine conjugates [146]