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It is also shown in animal models to bolster biochemical feedback mechanisms along the gut-brain axis [2, 4, 22]

COA 3

10.1016/S1097-2765(00)80017-9 22 GallinaA.HanleyT
Glutamine administration in patients undergoing cardiac surgery and the influence on blood glutathione levels

In this setting, excessive ROS act as active signaling mediators rather than passive metabolic byproducts