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The nucleophilic attack of an amino group toward the enzyme intermediate is more efficient than that of water
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It also recruits GLUT-4 receptors to the surface of muscle cells, facilitating glucose uptake from the bloodstream

Neuroscience 129:349360 Mercier C, Masseguin C, Roux F, Gabrion J, Scherrmann JM (2004) Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes
