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Given that manganese is typically excreted through bile rather than through urine, this observation may suggest a partial diversion in Mn excretion to urine due to kidney dysfunction

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Takada A., Bannai S

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Superoxide radical can be generated by specialized enzymes, such as the xanthine or NADPH oxidases, or as a by-product of cellular metabolism, particularly the mitochondrial electron transport chain, and are converted to hydrogen peroxide by the superoxide dismutase (SOD)