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Cancer genomic and transcriptomic data mining The transcriptome, copy-number alteration, mutations and corresponding clinical data of the TCGASKCM ( n = 473), TCGABRCA ( n = 1,215), TCGASTAD ( n = 450), TCGALUSC ( n = 553) and TCGAKIRC ( n = 606) datasets were retrieved from the National Cancer Institute Genomic Data Commons repository using the TCGAbiolinks R package in August 2022 (ref

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In the nucleus, Nrf2 binds to antioxidant response element (ARE) and triggers the transcription of numerous antioxidation-related genes, including NAD(P)H quinone dehydrogenase 1 (NQO1), Heme oxygenase-1 (HO-1), and glutathione peroxidase (GPx) (Yu and Xiao, 2021)