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Eustachian Tube Dysfunction

Among the cytokines, tumor necrosis factor (TNF) and IL-1 regulate leak pathway by promoting occludin endocytosis and MLCK activation [19, 23]

While more human clinical trials are needed, anecdotal reports and real-world results are encouraging

The biologically plausible assumption that biologic materials would resist infection and perform better in contaminated fields has not consistently translated into superior clinical outcomes

To maintain the cyclic structure of the LyP-1 peptide as well as the CendR motif, DOTA was conjugated with the -NH 2 of the cysteine at the N-terminus of LyP-1 either directly or via the 6-aminocaproic acid (ACP) spacer (Fig