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Both NAT1 and NAT2 are polymorphic enzymes, with 28 and 64 alleles having been identified to date (see for details of alleles

Coffee enemas may, however, help prevent kidney stones, since caffeine intake was associated with a reduced risk of this condition in a study on over 200k people

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Funding Statement This work was supported by the University of Zagreb, Zagreb, Croatia (grant BM 099) and the Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek (institutional scientificresearch project IP12 2023)