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To overcome these limitations, we propose that future strategies must prioritize lesion-focused drug delivery, such as nanocarriers and triggerable prodrugs, alongside biomarker-guided treatment regimens to decouple efficacy from systemic risk, paving a credible path for the clinical application of Erastin-class agents in EMS

14,15 Opioid receptors also develop during gestation and are considered to be widely distributed

Additionally, lifestyle changes, including diet and exercise, are typically necessary to complement the effects of oral medication

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[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, et al