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Model performance (goodness-of-fit and predictive ability) was assessed in the full testing set and in patients with independent (0-2) and dependent (3-5) mRS scores separately

Leyden J, Stephens T, Finkey MB, Appa Y, Barkovic S

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Moreover, PHGDH upregulation correlates with increased ROS generation, oxidative stress, and hypoxia-inducible factor-1 (HIF-1) activation, all of which promote metastasis in animal and cellular models ( D -2HG, linking glycolysis, serine metabolism, and oncometabolite production