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10.1016/j.intimp.2015.10.023 52 KongW

Metabolomics, 14 (11), 146

Yet, PSPH is recurrently amplified in a genomic region of focal copy number gain in 13% of the GBM brain tumors (TCGA copy number portal, 20130816 TCGA Pan-Cancer data set, Glioblastoma multiforme, n = 580, q value = 5.77 10 61 )

We hypothesized that the Nrf2-driven increase in expression of Slc7a11 and Gclc , and higher levels of GSH in KPK cells may result in export of glutamate in exchange for import of cystine (Figure 2A)
