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The following factors can increase the risk of mental health conditions in anyone, regardless of HIV status: Major life changes, such as the death of a loved one or the loss of a job Negative life experiences, such as abuse or trauma Biological factors, such as genes or brain chemistry A family history of mental health conditions In addition to these factors, the stress of having a medical condition like HIV may also negatively affect a person's mental health

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However, even some AO-selective high-affinity drugs such as the FDA-approved drugs aducanumab and donanemab, which activate the immune system in patients and cause it to clear AOs and amyloid plaques from the brain, require high doses to neutralize a small fraction of AOs (Sevigny et al., 2016