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Previous studies reported elevated cholesterol levels and oxidative stress in NPC1-deficient mice and patients with NPC1 [126,127]

In patients with locally advanced, metastatic, and/or refractory solid tumors and hematological malignancies, CB839 is being evaluated in open-label phase I clinical trials (NCT02071862, NCT02071888, NCT02771626)

318 : 187193 Pawson T (1994) Introduction: protein kinases

[DOI] [PMC free article] [PubMed] [Google Scholar] Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS

If you want to dig deep into the chemistry, you can view the chemical structure and molecular formula on the NIH website