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Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

Improved blood sugar if applicable

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Avoid using GLP-1 RAs if you have a personal or family history of medullary thyroid carcinoma or MEN2 syndrome (Multiple endocrine neoplasia type 2 syndrome)

By blocking NNMT activity, 5-Amino-1MQ raises intracellular SAM levels and simultaneously elevates NAD+ precursor availability creating conditions that research has associated with reduced fat cell differentiation and improved metabolic signaling