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VPS35 gene mutations can lead to mitochondrial dysfunction and autophagy defects, preventing the timely clearance of aggregated proteins and thereby promoting Lewy body formation, followed by damage to dopaminergic (DA) neurons [18]
Firstly, the use of BCPB results in clean chromatograms because the derivatization reaction does not yield byproducts and the detector analytical wavelength falls in the UV-region in which the biological matrix is usually transparent
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One effective one in this case is "The Many Faces of Cobalamin (B12) Deficiency"
10.1016/j.brainres.2004.05.049 Brain Res
