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Neuroprotection: Preclinical research has explored possible protective effects in age-related neurological studies

The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed

Additionally, HDAC2 deficiency also leads to decreased expression of Edn1 and Ednra (endothelin receptor type A) to alleviate renal injury

PE-22-28 also appears to have seizure-protective properties rather than seizure-promoting effects, which addresses one of the theoretical concerns with TrkB agonism

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Leal S.L., Landau S.M., Bell R.K., Jagust W.J