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Neuronal KCNQ potassium channels: physiology and role in disease

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Those leading to the production of a truncated protein, such as nonsense or frameshift mutations, tend to be linked to more severe disease than those caused by large deletions, missense mutations, and in-frame deletions.11 Patients who have mutations that result in truncated protein rather than loss of protein expression tend to present and be diagnosed at a much younger age than others and have a higher prevalence/proportion of meningiomas, spinal tumors, and other cranial nerve schwannomas (not VS)

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