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Even though a 48-h NAC treatment has been associated with about a 50-fold decrease in HBV assembly in HepG2-A5 cells [247], NAC has been revealed to be ineffective in acute viral B hepatitis treatment [287], However, other studies reported that NAC alone or in combination with other antiviral had no effects on plasma concentration of GSH, SOD and CAT for HBV [288,289] or HCV [290]

The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

Beatty S, Koh HH, Phil M et al (2000) The role of oxidative stress in the pathogenesis of age-related macular degeneration

doi: 10.1016/j.bbrc.2007.03.120

doi: 10.1016/j.toxlet.2017.06.008