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In addition to GSH effects with T cells, a decrease in GSH plays similar roles in MS as it does in AD and PD, namely, to mark an increase in oxidative stress and inflammation in the respective disease (Choi et al., 2018)

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(2016) Chloroplast activity and 3phosphadenosine 5phosphate signaling regulate programmed cell death in Arabidopsis

The pharmacological chaperone (ambroxol) treatment increased luminescence in GBA1 -HiBiT hPS cell-derived DA progenitor cells compared with DMSO-treated controls and elicited a clear luminescent increase only in GBA1 -HiBiT neurons 86 , providing a reliable, quantitative and real-time readout of endogenous PD risk gene products to elucidate PD mechanisms