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[DOI] [PMC free article] [PubMed] [Google Scholar] Lee S.E., Lee S.H

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These studies suggest that low circulating IGF-I bioactivity and/or abnormalities of IGF-I signaling in elderly subjects, may play an important role in age-related sarcopenia and osteopenia, where the substitutive IGF-I treatment may be a suitable therapeutic strategy, although this apparent IGF-I resistance may dampen this aim

Genomics 79 TakesawaT.ItoM.KanzakiH.KameyaN.NakamuraI