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For example, Vitamin C is essential for collagen production and skin repair, but it becomes "spent" once it neutralizes a free radical

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To investigate the effects of Thr starvation death further, we next performed a screen to determine whether withdrawal of essential AAs beyond Arg and Leu would influence threonine deprivationassociated cell death, and we prepared media lacking Thr combined with 13 other AAs individually dropped out (Fig 3H and I)

But I do want to mention there is a third aspect