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The brain substantia nigra in PD has a high level of expression of the VD metabolizing enzyme and 1 hydroxylase, and VD can stimulate the expression of tyrosine hydroxylase, a key enzyme of dopamine synthesis in PD, which affects the production and turnover of dopamine, therefore, the role of VD in the development process of PD has received increasing attention (85, 86)

doi: 10.3390/md9050757

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Phosphorylation of key signaling proteins like Akt, mTOR, and S6K occurs rapidly and can be measured using cell-level biology techniques

Jama 306, 15741581