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168 The consensus among experts is that due to the deleterious effect that elevated homocysteine levels has on both Parkinson's itself and L-DOPA therapy, supplementation with folate, B6, and B12 is warranted

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PLoS Med 3:e420 Singh RK, van Haandel L, Kiptoo P, Becker ML, Siahaan TJ, Funk RS (2019) Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model

While preclinical studies demonstrate promising results, clinical trials conducted thus far have yielded mixed outcomes, with some trials reporting limited or no therapeutic benefit