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We, therefore, targeted glutamine-glutamate metabolism, which is altered in KRAS mutants, using the glutamine synthetase inhibitor methionine sulfoximine (MSO) and the glutaminase inhibitor CB839 to avoid the toxicity that might result from targeting a key transcription factor such as FOXO1

2a ), a monocarbonyl curcumin analogue where the bismethoxyphenyl groups were connected by a penta-1,4-dien-3-one chain

2834 Wang S, Yan R, Wang B, Meng P, Tan W, Guo X (2019) The functional analysis of selenium-related genes and magnesium-related genes in the gene expression profile microarray in the peripheral blood mononuclear cells of Keshan disease

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10.1016/j.ejmech.2018.11.014 Eur