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For example, overexpression of ATP-binding cassette (ABC) transporters, including ABCB1 (P-glycoprotein) and ABCC1 (multidrug resistance-associated protein), increases the release of 5-FU from malignant cells, reducing its intracellular concentration and effectiveness (Rahmanian et al., 2021)
J Taibah Univ Medical Sci 1:19
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