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Description
As described in the previous section, oxidative stress originates mainly from the excessive production of ROS arising from mitochondrial oxidative phosphorylation

Limited drug bioavailability due to low vascularization is also a feature of hypoxic tumor cells (166)

McCormack JG, Halestrap AP, Denton RM

The efficacy of radiosensitization by Bi 2 S 3 -3BP was systematically evaluated both in vitro and in vivo

KLFs, particularly KLF2 and KLF4, are critical shear-responsive transcription factors that maintain the vascular barrier and endothelial quiescence by promoting anti-inflammatory and anti-thrombotic phenotypes and regulating metabolism [200, 201]
