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10.1016/j.ejphar.2013.05.029 60 SantiniS

298 Notably, mitochondrial copper can directly bind to proteins following their lipoylation, a post-translational modification involving the covalent attachment of an eight-carbon organosulfur lipoic acid moiety to specific lysine residues, leading to the aggregation of lipoylated proteins

This action results in a reduction of melanin content in the epidermis and could potentially help lighten the periorbital area, although clinical studies would be necessary to confirm this

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Another meta-analysis of randomized controlled trials found that endothelial function in normal-weight and overweight but not obese patients with type 2 diabetes was significantly improved by supplementation with vitamin E and/or vitamin C (90)