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When ROS overwhelms and surpasses the bodys antioxidants, the resulting oxidative stress accelerates mitochondrial dysfunction
Additionally, heme degradation and NCOA4-mediated ferritin autophagy can degrade ferritin, releasing iron into the labile iron pool (LIP) [64, 65], subsequently sensitizing cells to iron-induced atrophy via the Fenton response
K.KupsalK.ShyamalaN.et al (2018)
