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Small molecule inhibitors such as RSL3 and ML162 mediate alkylation on GPX4 by binding to the selenium cysteine 46 residue by electrophilic alkyl chloride moieties (Eaton et al., 2020

In addition to alterations in the antioxidant system, it should be noted that Nrf2 inhibition may result in modulations in signal transduction pathways such as MAPK cascades

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